Microsporidia and C. elegans papers:
Jiang J*, Qu R*, Grigorescu M, Zhao W, Reinke AW#. Functional consequences of reductive protein evolution in a minimal eukaryotic genome bioRxiv. 2024 Jan 1. doi.org/10.1101/2023.12.31.573788. See thread for more details.
van Himbeeck R, Sowa JN, Tamim El Jarkass H, Wu W, Vrielink JO, Riksen JAG, Reinke AW, van Sluijs L. Disease-decreasing diversity: evidence for lowered parasite prevalence in microscopic nematode communities with higher species numbers. bioRxiv 2023 Dec 9; doi.org/10.1101/2023.12.08.570776
Huang Q, Chen J, Pan G, Reinke AW#. Screening of the Pandemic Response Box identifies anti-microsporidia compounds. PLoS Negl Trop Dis . 2023 Dec 8;17(12):e0011806. doi: 10.1371/journal.pntd.0011806. See thread for more details.
Willis AR, Zhao W, Sukhdeo R, Burton NO, Reinke AW#. Parental dietary vitamin B12 causes intergenerational growth acceleration and protects offspring from pathogenic microsporidia and bacteria. bioRxiv. 2023 Sep 7. https://doi.org/10.1101/2023.09.05.556441.
Wadi L, Tamim El Jarkass H*, Tran TD*, Islah N, Luallen RJ, Reinke AW#. Genomic and phenotypic evolution of nematode-infecting microsporidia. PLoS Pathog. 2023 Jul 20;19(7):e1011510. doi: 10.1371/journal.ppat.1011510. See thread for more details.
Stratton CE, Reisinger LS, Behringer DC, Reinke AW, Bojko J. Alternosema astaquatica n. sp. (Microsporidia: Enterocytozoonida), a systemic parasite of the crayfish Faxonius virilis.J Invertebr Pathol. 2023 Jun 3:107948. doi: 10.1016/j.jip.2023.107948.
Mok C#, Xiao MA, Wan YC, Zhao W, Ahmed SM, Luallen RJ, Reinke AW#. High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits. PLoS Pathog. 2023 Mar 9;19(3):e1011225. doi: 10.1371/journal.ppat.1011225. See thread for more details.
Razvi E, Whitfield GB, Reichhardt C, Dreifus JE, Willis AR, Gluscencova OB, Gloag ES, Awad TS, Rich JD, da Silva DP, Bond W, Mauff FL, Sheppard DC, Hatton BD, Stoodley P, Reinke AW, Boulianne GL, Wozniak DJ, Harrison JJ, Parsek MR, Howell PL. Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ Biofilms Microbiomes. 2023 Feb 2;9(1):7. doi: 10.1038/s41522-023-00375-7.
Seroussi U, Lugowski A, Wadi L, Lao RX, Willis AR, Zhao W, Sundby AE, Charlesworth AG, Reinke AW, Claycomb JM. A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions. eLife. 2023 Feb 15;12:e83853. doi: 10.7554/eLife.83853.
Wan YC, Troemel ER, Reinke AW#. Conservation of Nematocida microsporidia gene expression and host response in Caenorhabditis nematodes. PLoS One . 2022 Dec 19;17(12):e0279103. doi: 10.1371/journal.pone.0279103. See thread for more details.
Murareanu BM, Antao NV, Zhao W, Dubuffet A, El Alaoui H, Knox J, Ekiert DC, Bhabha G, Roy PJ, and Reinke AW#.. High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans. Nat Commun. 2022 Sep 26;13(1):5653. doi: 10.1038/s41467-022-33400-y. See thread for more details.
Bojko J, Reinke AW, Stentiford GD, Williams B, Rogers MSJ, Bass D. Microsporidia: a new taxonomic, evolutionary, and ecological synthesis. Trends Parasitol. 2022 Jun 3;S1471-4922(22)00110-6. doi: 10.1016/j.pt.2022.05.007.
Willis AR and Reinke AW#. Factors That Determine Microsporidia Infection and Host Specificity. Exp Suppl. 2022;114:91-114. doi: 10.1007/978-3-030-93306-7_4.
Willis AR, Tamim El Jarkass H, Reinke AW#. Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection. Vis Exp. 2022 Apr 6;(182). doi: 10.3791/63636.
Tamim El Jarkass H, Mok C, Schertzberg MR, Fraser AG, Troemel ER, Reinke AW#. An intestinally secreted host factor limits bacterial colonization but promotes microsporidia invasion of C. elegans. eLife. 2022;11:e72458 DOI: 10.7554/eLife.72458 See thread for more details.
Burton N, Willis AR, Fisher K, Braukmann F, Price J, Stevens L, Baugh R, Reinke AW, Miska EA. Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs. eLife. 2021 Oct 8;10:e73425. doi: 10.7554/eLife.73425. See thread by Nick Burton for more details.
Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MR, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Res. 2021 Sep 7;49(15):8836-8865. doi: 10.1093/nar/gkab619. See thread by Julie Claycomb for more details.
Murareanu BM* Sukhdeo R*, Qu R*, Jiang J*, Reinke AW#. Generation of a Microsporidia Species Attribute Database and Analysis of the Extensive Ecological and Phenotypic Diversity of Microsporidia. mBio . 2021 Jun 29;e0149021. DOI: 10.1128/mBio.01490-21 *These authors contributed equally. #Corresponding Author. See thread for more details.
Willis AR*, Zhao W*, Sukhdeo R, Wadi L, Tamim El Jarkass H, Claycomb JM, Reinke AW#. A parental transcriptional response to microsporidia infection induces inherited immunity in offspring. Science Advances 05 May 2021;Vol. 7, no. 19, eabf3114
DOI: 10.1126/sciadv.abf3114. *These authors contributed equally. #Corresponding Author. See thread for more details.
Reinke AW#. 2021. mSphere of Influence: where the pathogen proteins are. mSphere May 2021, 6 (3) 6:e00365-21. https://doi.org/10.1128/mSphere.00365-21. #Corresponding Author.
Tamim El Jarkass H and Reinke AW#. The ins and outs of host-microsporidia interactions during invasion, proliferation and exit. Cell Microbiol. 2020 Aug 3:e13247. doi: 10.1111/cmi.13247. Online ahead of print. #Corresponding Author.
Willis AR, Sukhdeo R, Reinke AW#. Remembering your enemies: mechanisms of within-generation and multigenerational immune priming in Caenorhabditis elegans. FEBS J. 2020 Aug 7. doi: 10.1111/febs.15509. Online ahead of print. #Corresponding Author.
Wadi L and Reinke AW#. Evolution of microsporidia: An extremely successful group of eukaryotic intracellular parasites. PLoS Pathog. 2020 Feb 13;16(2):e1008276. doi: 10.1371/journal.ppat.1008276.#Corresponding author.
Reinke AW#, Mak R, Troemel ER, Bennett EJ. In vivo mapping of tissue- and subcellular-specific proteomes in Caenorhabditis elegans. Sci Adv. 2017 May 10;3(5):e1602426. doi: 10.1126/sciadv.1602426. #Corresponding author.
Reinke AW#, Balla KM, Bennett EJ, Troemel ER. Identification of microsporidia host exposed proteins reveals a repertoire of large paralogous gene families and rapidly evolving proteins. Nat. Commun. 2017 Jan 9;8:14023. doi: 10.1038/ncomms14023. #Corresponding author.
Luallen RJ, Reinke AW, Tong L, Botts MR, Felix MA, Troemel ER. Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans. PLoS Pathog. 2016 Jun 30; 12(6):e1005724. doi: 10.1371/journal.ppat.1005724.
Reinke AW, Troemel ER. The Development of Genetic Modification Techniques in Intracellular Parasites and Potential Applications to Microsporidia. PLoS Pathog. 2015 Dec;11(12):e1005283.
Other publications:
Rodríguez-Martínez JA*, Reinke AW*, Bhimsaria D*, Keating AE, Ansari AZ. Combinatorial dimerization of human bZIP transcription regulators confers preferences for different classes of DNA binding sites. Elife. 2017 Feb 10;6. pii: e19272. doi: 10.7554/eLife.19272.*These authors contributed equally to this work.
Kaplan JB, Reinke AW, Keating AE. Increasing the affinity of selective bZIP-binding peptides through surface residue redesign. Protein Sci. 2014 Jul;23(7):940-53. doi: 10.1002/pro.2477.
Reinke AW, Baek J, Ashenberg O, Keating AE. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4. doi: 10.1126/science.1233465.
Yin WB, Reinke AW, Szilágyi M, Emri T, Chiang YM, Keating AE, Pócsi I, Wang CC, Keller NP. bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology. 2013 Jan;159(Pt 1):77-88. doi: 10.1099/mic.0.063370-0.
Chen TS, Reinke AW, Keating AE. Design of peptide inhibitors that bind the bZIP domain of Epstein-Barr virus protein BZLF1. J Mol Biol. 2011 Apr 29;408(2):304-20. doi: 10.1016/j.jmb.2011.02.046.
Reinke AW, Grant RA, Keating AE. A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering. J Am Chem Soc. 2010 May 5;132(17):6025-31. doi: 10.1021/ja907617a.
Reinke AW, Grigoryan G, Keating AE. Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry. 2010 Mar 9;49(9):1985-97. doi: 10.1021/bi902065k.
Grigoryan G, Reinke AW, Keating AE. Design of protein-interaction specificity gives selective bZIP-binding peptides. Nature. 2009 Apr 16;458(7240):859-64. doi: 10.1038/nature07885.
Reinke A, Chen JC, Aronova S, Powers T. Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p. J Biol Chem. 2006 Oct 20;281(42):31616-26.
Reinke A, Anderson S, McCaffery JM, Yates J 3rd, Aronova S, Chu S, Fairclough S, Iverson C, Wedaman KP, Powers T. TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem. 2004 Apr 9;279(15):14752-62
Wedaman KP*, Reinke A*, Anderson S, Yates J 3rd, McCaffery JM, Powers T. Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell. 2003 Mar;14(3):1204-20. *These authors contributed equally to this work.